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- Title
Low HDL-C/ApoA-I index is associated with cardiometabolic risk factors and coronary artery calcium: a sub-analysis of the genetics of atherosclerotic disease (GEA) study.
- Authors
Cardoso-Saldaña, Guillermo Celestino; Antonio-Villa, Neftali Eduardo; Martínez-Alvarado, María del Rocío; González-Salazar, María del Carmen; Posadas-Sánchez, Rosalinda
- Abstract
Background: The high-density lipoprotein cholesterol to apolipoprotein A-I index (HDL-C/ApoA-I) may be practical and useful in clinical practice as a marker of atherosclerosis. This study aimed to investigate the association between the HDL-C/ApoA-I index with cardiometabolic risk factors and subclinical atherosclerosis. Methods: In this cross-sectional sub-analysis of the GEA study, 1,363 individuals, women (51.3%) and men (48.7%) between 20 and 75 years old, without coronary heart disease or diabetes mellitus were included. We defined an adverse cardiometabolic profile as excess adipose tissue metrics, non-alcoholic liver fat measured by non-contrasted tomography, metabolic syndrome, dyslipidemias, and insulin resistance. The population was stratified by quartiles of the HDL-C/Apo-AI index, and its dose-relationship associations were analysed using Tobit regression, binomial, and multinomial logistic regression analysis. Results: Body mass index, visceral and pericardial fat, metabolic syndrome, fatty liver, high blood pressure, and CAC were inversely associated with the HDL-C/ApoA-I index. The CAC > 0 prevalence was higher in quartile 1 (29.2%) than in the last quartile (22%) of HDL-C/ApoA-I index (p = 0.035). The probability of having CAC > 0 was higher when the HDL-C/ApoA-I index was less than 0.28 (p < 0.001). This association was independent of classical coronary risk factors, visceral and pericardial fat measurements. Conclusion: The HDL-C/ApoA-I index is inversely associated with an adverse cardiometabolic profile and CAC score, making it a potentially useful and practical biomarker of coronary atherosclerosis. Overall, these findings suggest that the HDL-C/ApoA-I index could be useful for evaluating the probability of having higher cardiometabolic risk factors and subclinical atherosclerosis in adults without CAD.
- Subjects
MEXICO; HIGH density lipoproteins; RISK assessment; CROSS-sectional method; ADIPOSE tissues; FATTY liver; HYPERLIPIDEMIA; BODY mass index; DATA analysis; STATISTICAL significance; RESEARCH funding; COMPUTED tomography; MULTIPLE regression analysis; ATHEROSCLEROSIS; CARDIOVASCULAR diseases risk factors; MULTIVARIATE analysis; DISEASE prevalence; CHI-squared test; DESCRIPTIVE statistics; CORONARY arteries; CALCIUM; INSULIN resistance; APOLIPOPROTEINS; METABOLIC syndrome; ANALYSIS of variance; STATISTICS; BLOOD pressure; DATA analysis software
- Publication
BMC Endocrine Disorders, 2024, Vol 24, Issue 1, p1
- ISSN
1472-6823
- Publication type
Article
- DOI
10.1186/s12902-024-01642-0