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- Title
Chemistry of polyhalogenated nitrobutadienes, 19: Synthesis of new types of compounds modulating the biological activity of Type I Interferons (IFN-I).
- Authors
Zapol'skii, Viktor A.; Bürgi, Milagros; Oggero, Marcos; Bollati-Fogolín, Mariela; Kaufmann, Dieter E.
- Abstract
The synthesis of ten new types of compound derived from polyhalonitroalkenes is described starting from the versatile solvent trichloroethene. The new compounds modulate the biological activity of Type I Interferons (IFN-I). Three of them (bornylamine derivative P6C11, chlorothiophene P28G6, and nitroindole P28F7) are promising candidates to inhibit rhIFN activity.
- Subjects
TYPE I interferons; TRICHLOROETHYLENE
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2023, Vol 2023, p1
- ISSN
1551-7004
- Publication type
Article
- DOI
10.24820/ark.5550190.p011.989