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- Title
F2L, a peptide derived from heme-binding protein, inhibits LL-37-induced cell proliferation and tube formation in human umbilical vein endothelial cells
- Authors
Lee, Sun Young; Lee, Mi-Sook; Lee, Ha Young; Kim, Sang Doo; Shim, Jae Woong; Jo, Seong Ho; Lee, Jae Won; Kim, Joon Youn; Choi, Young-Whan; Baek, Suk-Hwan; Ryu, Sung Ho; Bae, Yoe-Sik
- Abstract
Abstract: F2L, a peptide derived from heme-binding protein, was originally identified as an endogenous ligand for formyl peptide receptor-like (FPRL)2. Previously, we reported that F2L inhibits FPR and FPRL1-mediated signaling in neutrophils. Since endothelial cells express functional FPRL1, we examined the effect of F2L on LL-37 (an FPRL1 agonist)-induced signaling in human umbilical vein endothelial cells (HUVECs). F2L stimulated the chemotactic migration in HUVECs. However, F2L inhibited FPRL1 activity, resulting in the inhibition of cell proliferation and tube formation induced by LL-37 in HUVECs. We suggest that F2L will potentially be useful in the study of FPRL1 signaling and the development of drugs to treat diseases involving the FPRL1 in the vascular system.
- Subjects
CELL division; CELL proliferation; CELL growth; BLOOD vessels
- Publication
FEBS Letters, 2008, Vol 582, Issue 2, p273
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.12.015