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- Title
The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor
- Authors
Abderrahmani, Amar; Niederhauser, Guy; Lenain, Vincent; Regazzi, Romano; Waeber, Gérard
- Abstract
Abstract: Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and β-cells. In this study, we hypothesized that REST expression is controlled by hairy and enhancer of split 1 (HES-1), a transcriptional repressor that plays an important role in brain and pancreas development. We identified several N elements (CTNGTG) within the promoter of REST and confirmed that HES-1 associates with the endogenous promoter of REST. Moreover, using a cells model that overexpress HES-1 and a combination of experimental approaches, we demonstrated that HES-1 reduces endogenous REST expression. Taken together, these results indicate that HES-1 is an upstream negative regulator of REST expression.
- Subjects
ENDOCRINE glands; PANCREAS; GENETIC transcription; DIGESTIVE organs
- Publication
FEBS Letters, 2005, Vol 579, Issue 27, p6199
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.09.093