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- Title
Stereotactic body radiation therapy for hepatocellular carcinoma: Experience from a tertiary cancer care center in India.
- Authors
Madhavan, R.; Kunher, B.; Arunlal, M.; Nair, H. M.; Unnikrishnan, U. G.; Holla, R.; Makuny, D.
- Abstract
<bold>Aim: </bold>The aim of this retrospective study is to assess the toxicity and tumor response of stereotactic body radiation therapy (SBRT) protocol for hepatocellular carcinoma (HCC) in our institution.<bold>Background: </bold>Hepatocellular cancer is one of the leading cancers among men in India. In recent years, SBRT has emerged as a promising tool in the treatment of HCC.<bold>Materials and Methods: </bold>Ten patients diagnosed as HCC with Barcelona Clinic Liver Cancer Stage B and C, treated with SBRT technique from January 2013 to December 2016, were included in this study. SBRT was delivered using 6 MV photons with volumetric modulated arc therapy. Acute and late toxicities were graded, and tumor response was assessed using response evaluation criteria in solid tumors criteria. Kaplan-Meier curves were generated for progression-free survival (PFS) and overall survival (OS).<bold>Results: </bold>The median age was 61.5 (52-69) years. The radiation dose ranged from 35 Gy to 60 Gy. All patients obtained partial response during assessment at 3 months after completion of treatment. The median PFS is 8 months (95% confidence interval [CI] - 5.22-10.77 months). The median OS is 51 months (95% CI - 17.64-65.10 months). The OS at 1 and 2 years is 75% and 57%, respectively.<bold>Conclusions: </bold>SBRT is well tolerated by our patients. The 1- and 2-year OS of 75% and 57% is consistent with other prospective and retrospective SBRT studies from the literature.
- Subjects
INDIA; LIVER cancer; TUMOR treatment; LIVER tumors; RADIOTHERAPY; CANCER chemotherapy; SORAFENIB; INDIAN Council of Medical Research (Organization); HEPATOCELLULAR carcinoma; RADIOSURGERY; SPECIALTY hospitals
- Publication
Indian Journal of Cancer, 2017, Vol 54, Issue 1, p316
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/ijc.IJC_156_17