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- Title
Hypofractionated radiotherapy for localized prostate cancer using three-dimensional conformal radiotherapy technique: 3 years toxicity analysis.
- Authors
R., White; D., Woolf; S., Li; R., Alonzi; P., Osler; P., Hoskin; R., Hughes; White, R; Woolf, D; Li, S; Alonzi, R; Osler, P; Hoskin, P; Hughes, R
- Abstract
<bold>Background: </bold>Hypofractionated radiotherapy in the radical treatment of localized prostate cancer has potential biological advantages relative to conventional fractionation. We report prospectively collected toxicity data from a cohort of patients treated with a 3D conformal technique (3DCRT).<bold>Materials and Methods: </bold>90 patients receiving curative intent hypofractionated radiotherapy with 57Gy in 19 daily fractions over 3.8 weeks were evaluated prospectively for the development of radiation related toxicity over a 3 year period.<bold>Results: </bold>All patients completed treatment. Maximal acute toxicity experienced was 58.6, 10 and 1.1% for grade 1, 2 and 3 genitourinary (GU) toxicity respectively and 75.6, 9 and 0% for gastrointestinal (GI) toxicity. For late toxicity the three year actuarial rates of grade 1, 2 and 3 GU and GI toxicity respectively were 47.3, 2.4 and 0%; and 40, 9.3 and 4.7%. There were no grade 4 or worse acute or late toxicities. 97.6% of evaluable patients remained free of biochemical failure 36 months post radiotherapy.<bold>Conclusions: </bold>A 57Gy in 19 daily fraction radiotherapy schedule using 3D conformal radiotherapy for the definitive treatment of localized prostate cancer has acceptable early and late toxicity.
- Subjects
RADIOTHERAPY; PROSTATE cancer treatment; PHYSIOLOGICAL effects of radiation; CANCER treatment; CANCER patient care; PHYSIOLOGY
- Publication
Indian Journal of Cancer, 2015, Vol 52, Issue 4, p654
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/0019-509X.178409