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- Title
Clinical and laboratory features associated with acute kidney injury in severe malaria.
- Authors
Anghan, Hiren; Sethi, Prayas; Soneja, Manish; Mahajan, Sandeep; Wig, Naveet
- Abstract
Introduction: Critically ill severe malaria constitutes one of the major hospital admissions in Indian setting. Clinical studies identifying the factors associated with acute kidney injury (AKI) in malaria are lacking. This study aimed to identify these factors. Methods: This prospective observational study was conducted in a tertiary care center of North India. All adult patients with severe malaria were studied during 2012–2014. Results: The study included 79 patients and AKI was observed in 36 patients. Of these 79 patients, 52.7% were Plasmodium falciparum positive and 47.2% were Plasmodium vivax positive. In AKI patients, thrombocytopenia and jaundice were the most common other complications seen. Among P. vivax malarial patients, 17 (36%) patients had AKI. Features associated with AKI among patients admitted with P. vivax malaria were as follows: tachycardia (adjusted relative risk [RR]: 3.9; 95% confidence interval [CI]: 1.1–13.7), direct hyperbilirubinemia (adjusted RR: 4.7; 95% CI: 1.4–15.2), anemia (adjusted RR: 6; 95% CI: 1.7–22.4), and sepsis (adjusted RR: 3.3; 95% CI: 1.1–13.7). The presence of tachycardia, acidosis, cerebral malaria, acute respiratory distress syndrome/acute lung injury, hypotensive shock, and poor Glasgow Coma Scale were associated with higher mortality in patients with AKI. Patients who required mechanical ventilation and/or vasopressor support had higher mortality. Conclusion: P. vivax is an important cause of severe malaria with AKI in our setting. Various other clinical features are associated with AKI and related mortality.
- Subjects
ACUTE kidney failure; ANEMIA; CONFIDENCE intervals; HYPERBILIRUBINEMIA; JAUNDICE; LONGITUDINAL method; MALARIA; SCIENTIFIC observation; SEPSIS; TACHYCARDIA; THROMBOCYTOPENIA; DISEASE complications; DISEASE risk factors
- Publication
Indian Journal of Critical Care Medicine, 2018, Vol 22, Issue 10, p718
- ISSN
0972-5229
- Publication type
Article
- DOI
10.4103/ijccm.IJCCM_468_17