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- Title
Radiolabeling and evaluation of fonturacetam hydrazide as a radiotracer for visualization of brain function.
- Authors
El-Kawy, O. A.; Shweeta, H. A.; Sallam, Kh. M.
- Abstract
[99mTc] fonturacetam hydrazide was radiosynthesized to assess neuropsychiatric disorders by targeting the brain. The nootropic drug was labeled with technetium-99m, and factors affecting the labeling yield were studied. At optimum conditions, the radiocomplex was obtained at a high radiochemical yield (98.9%) and was stable in saline for up to 36 h and serum for more than 24 h. Labeled fonturacetam hydrazide was characterized and assessed in silico. Biodistribution studies in mice showed that the brain uptake of the complex was 8.8% injected dose per gram (% ID/g) at 5 min post-injection, surpassing the commercially available [99mTc] ECD (4.7% ID/g) and [99mTc] HMPAO (2.25% ID/g). All results suggested that the tracer is a good candidate to image the human brain for assessing neuropsychiatric disorders.
- Subjects
RADIOACTIVE tracers; RADIOLABELING; NEUROBEHAVIORAL disorders; DATA visualization; DRUG labeling; NOOTROPIC agents
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2023, Vol 332, Issue 8, p3273
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-023-08966-6