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- Title
Functionalization of Silk by AIEgens through Facile Bioconjugation: Full‐Color Fluorescence and Long‐Term Bioimaging.
- Authors
Liu, Chenchen; Bai, Haotian; He, Benzhao; He, Xuewen; Zhang, Jianyu; Chen, Chao; Qiu, Yanping; Hu, Rong; Zhao, Fangxin; Zhang, Yunxiao; He, Wei; Chau, Joe H. C.; Chen, Sijie; Lam, Jacky W. Y.; Tang, Ben Zhong
- Abstract
Silkworm silk is a promising natural biopolymer for textile and biomedical applications for its remarkable flexibility, excellent biocompatibility and controllable biodegradability. The functionalization of silks makes them more versatile for flexible displays and visible bioscaffolds. However, fluorescent silks are normally fabricated through unstable physical absorption or complicated chemical reactions under harsh conditions. Herein, we developed a simple strategy for preparing fluorescent silks. Five aggregation‐induced emission luminogens (AIEgens) with activated alkynes were synthesized by rational molecular design, and then reacted with silk fibers through facile metal‐free click bioconjugation. The resulting conjugates show bright full‐color emissions and high stability. A white light‐emitting silk was fabricated by simultaneous bioconjugation with red‐, green‐ and blue‐emissive AIEgens. The red‐emissive AIEgen‐functionalized silks were successfully applied for long‐term cell tracking and two‐photon bioimaging, demonstrating great potential for tissue engineering and bioscaffold monitoring.
- Subjects
COMPUTER-assisted molecular design; FLEXIBLE display systems; SILK; FLUORESCENCE; TISSUE engineering
- Publication
Angewandte Chemie, 2021, Vol 133, Issue 22, p12532
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202015592