We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MicroRNAs and colorectal cancer: clinical potential and regulatory networks.
- Authors
Osei, George Yiadom; Adu-Amankwaah, Joseph; Koomson, Selina; Beletaa, Solomon; Asiamah, Emmanuel Akomanin; Smith-Togobo, Cecilia; Razak, Siti Razila Abdul
- Abstract
Colorectal cancer (CRC) is a serious global health concern, with a high incidence and mortality rate. Although there have been advancements in the early detection and treatment of CRC, therapy resistance is common. MicroRNAs (miRNAs), a type of small non-coding RNA that regulates gene expression, are key players in the initiation and progression of CRC. Recently, there has been growing attention to the complex interplay of miRNAs in cancer development. miRNAs are powerful RNA molecules that regulate gene expression and have been implicated in various physiological and pathological processes, including carcinogenesis. By identifying current challenges and limitations of treatment strategies and suggesting future research directions, this review aims to contribute to ongoing efforts to enhance CRC diagnosis and treatment. It also provides a comprehensive overview of the role miRNAs play in CRC carcinogenesis and explores the potential of miRNA-based therapies as a treatment option. Importantly, this review highlights the exciting potential of targeted modulation of miRNA function as a therapeutic approach for CRC.
- Subjects
COLORECTAL cancer; NON-coding RNA; GENE expression; THERAPEUTICS; CARCINOGENESIS; NEUROPEPTIDES
- Publication
Molecular Biology Reports, 2023, Vol 50, Issue 11, p9575
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-023-08810-w