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- Title
Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population.
- Authors
Cadena-Sandoval, Daniel; Alemán-Ávila, Isidro; Barbosa-Cobos, Rosa Elda; Becerril-Mendoza, Lizbeth Teresa; Fragoso, José Manuel; Ramírez-Bello, Julián
- Abstract
Tumor necrosis factor (TNF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Different genetic variants including the TNF −308G/A polymorphism are associated with RA susceptibility. However, these findings have not been replicated in all populations. The aim of this study was to determine whether the TNF −1031T/C (rs1799964), −376G/A (rs1800750), −308G/A (rs1800629) −238G/A (rs361525), and TNFR1 −609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients. Our study included 499 patients with RA and 492 healthy controls. The genotypes of the TNF polymorphisms were obtained using TaqMan assay. The genotype and allele frequencies of the TNF −1031T/C, −376G/A, −308G/A, −238G/A, and TNFR1 −609G/T polymorphisms were similar among RA cases versus healthy controls, and no association with RA susceptibility was identified. Our results suggest that the TNF −1031T/C, −376G/A, −308G/A, −238G/A, and TNFR1 −609G/T polymorphisms are not associated with RA susceptibility in a sample of Mexican patients.
- Subjects
TUMOR necrosis factors; GENETIC polymorphisms; RHEUMATOID arthritis; GENETICS of disease susceptibility; GENE frequency; PATIENTS
- Publication
Molecular Biology Reports, 2018, Vol 45, Issue 3, p227
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-018-4155-2