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- Title
Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population.
- Authors
Yin, Jun; Tang, Weifeng; Shao, Aizhong; Wang, Liming; Wang, Xu; Ding, Guowen; Liu, Chao; Chen, Yijang; Chen, Suocheng; Gu, Haiyong
- Abstract
Esophageal cancer is one of the ten most common cancers in the world and has poor prognosis. Apoptosis is considered a fundamental component in cancer pathogenesis. We conducted a hospital-based case-control study to evaluate the genetic effects of 16 apoptosis associated single nucleotide polymorphisms (SNPs) on esophageal cancer development. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. Genotypes were determined using a custom-by-design 48-Plex SNPscan™ Kit. The caspase8 ( CASP8) rs1035142 G>T polymorphism was associated with increased risk of ESCC by heterozygote comparison, homozygote comparison, a dominant genetic model and a recessive genetic model. However, no significant association was detected between the other 15 SNPs and ESCC risk. Stratified analyses indicated a significantly increased risk of ESCC associated with CASP8 rs1035142 G>T polymorphism was evident among all subgroups. These findings indicated that the functional polymorphism CASP8 rs1035142 G>T might contribute to ESCC susceptibility.
- Subjects
CASPASES; GENETIC polymorphisms; ESOPHAGEAL cancer; GENETIC models; APOPTOSIS
- Publication
Molecular Biology Reports, 2014, Vol 41, Issue 4, p2037
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-014-3052-6