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- Title
COMPREHENDING COVID-19: IMMUNOPATHOGENIC MECHANISMS OF CYTOKINE ACTION.
- Authors
AKANBONG, Elisha Apatewen; DEVRİM, Alparslan Kadir; ŞENOL, Ali; DEVRİM, Tuba
- Abstract
Cytokine release syndrome (CRS) or cytokine storm is as a result of the excess production of pro-inflammatory cytokines which is due to the disproportionate response of the immune system which can be instigated by SARS-CoV-2. COVID-19 which is caused by SARS-CoV-2 has a correlation with cytokines. SARS-CoV-2 instigates the production of IL-1 by ubiquitous macrophages and mast cells. IL-1 tends to influence the production of IL-6 and TNF-α. The progression of COVID-19 severity influences the level of certain cytokines such as IL-6. IL-6 is the cytokine chiefly responsible for the occurrence of CRS. CRS is the cause of COVID-19-related complications and the main cause of COVID-19-related deaths. Despite the data reported in the literature so far, the relationship between SARS-CoV-2 and cytokines has not been fully elucidated. The aim of the present review is to examine the relationship in question. Targeting cytokines during COVID-19 treatment has the potential to increase patient survival and reduce COVID-19-related deaths. It is concluded that focusing on the mechanisms of cytokine release and the effects of released cytokines, especially examining the effects on T lymphocytes and IFN-γ production in COVID-19 disease, may help reduce the lethal effects of the disease.
- Subjects
CYTOKINES; CORONAVIRUS diseases; IMMUNE system; SARS disease; MAST cells
- Publication
Medical Journal of Suleyman Demirel University, 2021, Vol 28, Issue 4, p687
- ISSN
1300-7416
- Publication type
Article
- DOI
10.17343/sdutfd.971047