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- Title
Mid-term outcomes of surgical aortic valve replacement using a mosaic porcine bioprosthesis with concomitant mitral valve repair.
- Authors
Sugimori, Haruhiko; Nakao, Tatsuya; Okada, Yukikatsu; Okita, Yutaka; Yaku, Hitoshi; Kobayashi, Junjiro; Uesugi, Hideyuki; Takanashi, Shuichiro; Ito, Toshiaki; Koyama, Tadaaki; Sakaguchi, Taichi; Yamamoto, Kouji; Yoshikawa, Yasushi; Sawa, Yoshiki
- Abstract
This study retrospectively evaluated the mid-term outcomes of surgical aortic valve replacement (SAVR) using a stented porcine aortic valve bioprosthesis (Mosaic; Medtronic Inc., Minneapolis, MN, USA) with concomitant mitral valve (MV) repair. From 1999 to 2014, 157 patients (median [interquartile range] age, 75 [70–79] years; 47% women) underwent SAVR with concomitant MV repair (SAVR + MV repair), and 1045 patients (median [interquartile range] age, 76 [70–80] years; 54% women) underwent SAVR only at 10 centers in Japan as part of the long-term multicenter Japan Mosaic valve (J-MOVE) study. The 5-year overall survival rate was 81.5% ± 4.1% in the SAVR + MV repair group and 85.1% ± 1.4% in the SAVR only group, and the 8-year overall survival rates were 75.2% ± 5.7% and 78.1% ± 2.1%, respectively. Cox proportional hazards analysis showed no significant difference in the survival rates between the two groups (hazard ratio, 0.87; 95% confidence interval, 0.54–1.40; P = 0.576). Among women with mild or moderate mitral regurgitation who were not receiving dialysis, those who underwent SAVR + MV repair, were aged > 75 years, and had a preoperative left ventricular ejection fraction of 30–75% tended to have a lower mortality risk. In conclusion, this subgroup analysis of the J-MOVE cohort showed relevant mid-term outcomes after SAVR + MV repair.
- Subjects
JAPAN; AORTIC valve transplantation; MITRAL valve; VENTRICULAR ejection fraction; BIOPROSTHESIS; AORTIC valve; MITRAL valve insufficiency
- Publication
Heart & Vessels, 2024, Vol 39, Issue 3, p252
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-023-02325-x