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- Title
Improved quantification precision of human brain short echo-time <sup>1</sup>H magnetic resonance spectroscopy at high magnetic field: A simulation study.
- Authors
Deelchand, Dinesh Kumar; Iltis, Isabelle; Henry, Pierre‐Gilles
- Abstract
Purpose The gain in quantification precision that can be expected in human brain 1H MRS at very high field remains a matter of debate. Here, we investigate this issue using Monte-Carlo simulations. Methods Simulated human brain-like 1H spectra were fitted repeatedly with different noise realizations using LCModel at B0 ranging from 1.5T to 11.7T, assuming a linear increase in signal-to-noise ratio with B0 in the time domain, and assuming a linear increase in linewidth with B0 based on experimental measurements. Average quantification precision (Cramér-Rao lower bound) was then determined for each metabolite as a function of B0. Results For singlets, Cramér-Rao lower bounds improved (decreased) by a factor of ∼
- Publication
Magnetic Resonance in Medicine, 2014, Vol 72, Issue 1, p20
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.24892