We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recurrent High-Dose Intravenous Methylprednisolone Succinate Pulse Therapy-Induced Hepatopathy in a Patient with Multiple Sclerosis.
- Authors
Furutama, Daisuke; Kimura, Fumiharu; Shinoda, Keiichi; Maeda, Tamaki; Tanaka, Toshifumi; Ohsawa, Nakaaki
- Abstract
Objective: We describe recurrent and reversible hepatopathy in a girl with multiple sclerosis (MS) after glucocorticoid pulse therapy, to point out the possibility that glucocorticoid may harm the liver. Clinical Presentation and Intervention: An 11-year-old girl with MS, who was treated with high-dose methylprednisolone succinate pulse therapy, developed elevation of liver enzymes. The episodes of hepatopathy occurred 1-5 weeks after the therapy and disappeared within several weeks. The examination for antinuclear antibody and viruses which can cause hepatitis produced negative results. Conclusion: The present case emphasizes the possible effects of high-dose glucocorticoids in the induction of liver enzymes and the importance of follow-up liver tests after pulse therapy. Copyright © 2011 S. Karger AG, Basel
- Subjects
CASE studies; MULTIPLE sclerosis treatment; THERAPEUTICS; GLUCOCORTICOIDS; SUCCINATE dehydrogenase
- Publication
Medical Principles & Practice, 2011, Vol 20, Issue 3, p291
- ISSN
1011-7571
- Publication type
Article
- DOI
10.1159/000323835