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- Title
Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives.
- Authors
Aksenov, Alexander V.; Kirilov, Nikita K.; Aksenov, Nicolai A.; Arutiunov, Nikolai A.; Aksenov, Dmitrii A.; Rubin, Michael
- Abstract
Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the presence of polyphosphoric acid.
- Subjects
AMINO acid derivatives; NITROALKANES; POLYPHOSPHORIC acid; AMINO acids; ALKYLAMINES
- Publication
Chemistry of Heterocyclic Compounds, 2022, Vol 58, Issue 1, p32
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-022-03053-2