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- Title
α-Substituted β-mercapto ketone based synthesis of 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles.
- Authors
Baeva, Larisa А.; Nugumanov, Radik M.; Gataullin, Rail R.; Fatykhov, Akhnef А.
- Abstract
A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1H-indoles was developed based on the Fischer indole synthesis involving accessible β-mercapto ketones. Heterocyclization of 3-[(alkylsulfanyl)methyl]alkan-2-ones and phenylhydrazine by the action of ZnCl2 in MeOH or EtOH gave previously unknown 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles.
- Subjects
KETONES; PHENYLHYDRAZINE; INDOLE
- Publication
Chemistry of Heterocyclic Compounds, 2021, Vol 57, Issue 5, p543
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-021-02940-4