We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae).
- Authors
Paula de Oliveira, Ana; Santin, José Roberto; Lemos, Marivane; Klein Júnior, Luiz Carlos; Couto, Angélica Garcia; Meyre da Silva Bittencourt, Christiane; Filho, Valdir Cechinel; Faloni de Andrade, Sérgio
- Abstract
Objectives The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare. Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms of gastroprotection were also undertaken. Key findings In the model of ethanol-induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31 ± 0.57, 74.31 ± 0.91 and 79.86 ± 0.59 for the groups treated with 50 and 100 mg/kg of extract of M. vulgare and omeprazole (30 mg/kg), respectively. For indomethacin-induced ulcers, the percentages of ulcer inhibition were 50.32 ± 5.60, 66.24 ± 4.30, 82.17 ± 04.09 and 67.52 ± 4.38, for the groups treated with 25, 50 and 100 mg/kg M. vulgare and positive control (cimetidine), respectively. In both models, the marrubiin (25 mg/kg) produced a significant reduction in all the parameters when compared with the control group ( P < 0.01). There was also a significant increase in pH and mucus production in the groups treated with M. vulgare extract and marubiin. The results also demonstrated that the gastroprotection induced by the extract and marubiin is related to the activity of nitric oxide and endogenous sulfhydryls, which are important gastroprotective factors. Conclusions The results of this study show that the extract of M. vulgare and marrubiin displays antiulcer activity and that this effect can be partly attributed to the isolated diterpene.
- Subjects
DITERPENES; MARRUBIUM; LABORATORY mice; CONTROL groups; MUCUS; NITRIC oxide
- Publication
Journal of Pharmacy & Pharmacology, 2011, Vol 63, Issue 9, p1230
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/j.2042-7158.2011.01321.x