We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Racial variation in cardiovascular disease risk factors among European children on renal replacement therapy--results from the European Society for Paediatric Nephrology/European Renal Association - European Dialysis and Transplant Association Registry.
- Authors
Tjaden, Lidwien A.; Jager, Kitty J.; Bonthuis, Marjolein; Kuehni, Claudia E.; Lilien, Marc R.; Seeman, Tomas; Stefanidis, Constantinos J.; Tse, Yincent; Harambat, Jérôme; Groothoff, Jaap W.; Noordzij, Marlies
- Abstract
Background. Racial differences in overall mortality rates have been found in children on renal replacement therapy (RRT).We used data from the European Society for Paediatric Nephrology/European Renal Association - European Dialysis and Transplant Association Registry to study racial variation in the prevalence of cardiovascular disease (CVD) risk factors among European children on RRT. Methods. We included patients aged<20 years between 2006-13 who (i) initiated dialysis treatment or (ii) had a renal transplant vintage of1 year. Racial groups were defined as white, black, Asian and other. The CVD risk factors assessed included uncontrolled hypertension, obesity, hyperphosphataemia and anaemia. Differences between racial groups in CVD risk factors were examined using generalized estimating equation (GEE) models while adjusting for potential confounders. Results. In this study, 1161 patients on dialysis and 1663 patients with a transplant were included. The majority of patients in both groups were white (73.8% and 79.9%, respectively). The crude prevalence of the CVD risk factors was similar across racial groups. However, after adjustment for potential confounders, Asian background was associated with higher risk of uncontrolled hypertension both in the dialysis group [odds ratio (OR): 1.27; 95% confidence interval (CI): 1.01-1.64] and the transplant group (OR: 1.37; 95% CI: 1.11-1.68) compared with white patients. Patients of Asian and other racial background with a renal transplant had a higher risk of anaemia compared with white patients (OR: 1.50; 95% CI: 1.15-1.96 and OR: 1.45; 95% CI: 1.01-2.07, respectively). Finally, the mean number of CVD risk factors among dialysis patients was higher in Asian patients (1.83, 95% CI: 1.64-2.04) compared with white patients (1.52, 95% CI: 1.40-1.65). Conclusions. We found a higher prevalence of modifiable CVD risk factors in Asian children on RRT. Early identification and management of these risk factors could potentially improve long-term outcomes.
- Subjects
CARDIOVASCULAR diseases risk factors; EUROPEAN Dialysis &; Transplant Nurses Association; KIDNEY transplantation; JUVENILE diseases; DISEASE prevalence
- Publication
Nephrology Dialysis Transplantation, 2017, Vol 32, Issue 11, p1908
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfw423