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- Title
血清Toll样受体9与创伤致脓毒症患者预后的关系.
- Authors
唐国强; 胡惠; 曾涌
- Abstract
Objective To investigate the relationship between serum Toll-like receptor 9 (TLR9) levels and the prognosis of patients with sepsis caused by trauma. Methods Fifty-three patients with post-traumatic sepsis (sepsis group), 208 patients without sepsis (non-sepsis group), and 63 physical examination volunteers (control group) treated at the Chongqing Emergency Medical Center from August 2020 to August 2022 were selected. Serum TLR9 levels in trauma patients were detected at 1 h (T0), 3 h (T1), 6 h (T2), 12 h (T3), 24 h (T4), 48 h (T5), and 72 h (T6) after admission (day of physical examination in the control group). The risk factors for nosocomial death in patients with trauma-induced sepsis and the value of TLR9 in predicting nosocomial death were analyzed. Results The serum TLR9 level in the sepsis and non-sepsis groups at T0 was higher than that in the control group (P < 0.05). The serum TLR9 level at T1 to T6 in the sepsis group was higher than that in the non-sepsis group (P < 0.05). The serum TLR9 level of T4 to T6 in the death group was higher than that in the survival group (P < 0.05). A baseline SOFA score ≥17 and TLR9 level at T6 time point≥3 pg/mL were risk factors for nosocomial death in patients with sepsis caused by trauma (P < 0.05). The areas under the curve of TLR9 level at T6 time point, baseline SOFA score, and their combined prediction of in-hospital mortality in patients with trauma-induced sepsis were 0.719, 0.754, and 0.824, respectively. Conclusion Serum TLR9 levels were significantly increased in patients with trauma-induced sepsis, which is associated with nosocomial death and can be used as an auxiliary indicator for prognosis assessment.
- Publication
Journal of China Medical University, 2024, Vol 53, Issue 4, p337
- ISSN
0258-4646
- Publication type
Article
- DOI
10.12007/j.issn.0258‐4646.2024.04.008