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- Title
Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints.
- Authors
Ghilardi, Maria Gabriela S.; Campos, Ana Carolina P.; Cury, Rubens G.; Martinez, Raquel C. R.; Pagano, Rosana L.; Fonoff, Erich T.
- Abstract
Pain control after deep brain stimulation (DBS) in Parkinson's disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endorphin level. Pallidal GPi-DBS decreased bodily discomfort and beta-endorphin levels. Unexplained pain by other conditions and bodily discomfort were negatively correlated with beta-endorphin levels. Thus, DBS regulates central opioids, and prioritizing STN is important for PD patients with significant sensory complications.
- Subjects
DEEP brain stimulation; SUBTHALAMIC nucleus; GLOBUS pallidus; PARKINSON'S disease; PAIN management
- Publication
NPJ Parkinson's Disease, 2024, Vol 10, Issue 1, p1
- ISSN
2373-8057
- Publication type
Article
- DOI
10.1038/s41531-024-00689-z