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- Title
The Impact of Alcohol Consumption Pattern on Liver Fibrosis in Asymptomatic Patients.
- Authors
Minea, Horia; Singeap, Ana-Maria; Sfarti, Catalin Victor; Girleanu, Irina; Chiriac, Stefan; Muzica, Cristina; Cuciureanu, Tudor; Petrea, Oana Cristina; Huiban, Laura; Zenovia, Sebastian; Nastasa, Robert; Rotaru, Adrian; Stafie, Remus; Stratina, Ermina; Cojocariu, Camelia; Stanciu, Carol; Trifan, Anca
- Abstract
Introduction: Alcohol consumption (AC) represents a widespread cause of liver diseases affecting 10–20% of the population. The study aimed to evaluate the relationship between advanced liver fibrosis (ALF) measured by transient elastography (TE), laboratory parameters, and the amount of AC depending on non-modifiable risk factors such as age and gender. Methods: We examined 689 patients with an average age of 49.32 ± 14.31 years, 72.9% males, without liver pathology, who admitted a moderate/high consumption (female ≤ 7 versus > 7 drinks/week; male ≤ 14 versus > 14 drinks/week) for at least five years. The fibrosis level was adjusted according to transaminase levels. Predictive factors were established using univariate regression analysis. Results: ALF (≥F3) was detected in 19.30% of subjects, predominantly males (14.1%) and patients over 55 years (12.5%). Excessive consumption of distilled spirits is associated with ALF in females (OR = 4.5), males (OR = 6.43) and patients over 55 years (OR = 3.73). A particularity highlighted in both genders, regardless of the age group, was the negative correlation between the decrease in the number of platelets, the albumin concentration, and the appearance of AFL. Conclusions: Screening using TE represents an approach for early detection of ALF in asymptomatic populations and the development of a risk stratification scheme.
- Subjects
HEPATIC fibrosis; ASYMPTOMATIC patients; ALCOHOL drinking; CONSUMPTION (Economics); AGE groups
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 23, p7405
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12237405