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- Title
Microbiome of Acute Otitis Externa.
- Authors
Kim, Sung Kyun; Han, Sung Jun; Hong, Seok Jin; Hong, Seok Min
- Abstract
Background: Ear canal skin is directly attached to bone or cartilage, and is also connected to the eardrum. Acute otitis externa is cellulitis of the ear canal skin and subdermal tissue associated with acute inflammation and variable edema. We characterized the microbiome of the normal ear canal and ear canal with otitis externa. Methods: In total, 28 samples (14 each from the ear canal skin of patients with acute otitis externa and normal healthy controls) were collected using swabs. DNA extraction and bacterial microbiome analysis via 16S rRNA gene sequencing were performed. Results: The diversity index (mean amplicon sequence variants and Shannon index) were lower in the otitis externa than control group. According to linear discriminant effect size (LEfSe) analysis, a number of taxa differed significantly between the groups. Pseudomonas at the genus level and Staphylococcus warneri at the species level were identified in the otitis externa group. Conclusion: Our results show the importance of the microbiome in the pathogenesis of otitis externa and provide a basis for treating acute otitis externa by targeting the microbiome.
- Subjects
OTITIS externa; EAR canal; BACTERIAL DNA; TYMPANIC membrane; CELLULITIS
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 23, p7074
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11237074