We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Safety, Feasibility and Technical Considerations from a Prospective, Observational Study—CIREL: Irinotecan-TACE for CRLM in 152 Patients.
- Authors
Helmberger, Thomas; Lucatelli, Pierleone; Pereira, Philippe L.; Gjoreski, Aleksandar; Jovanoska, Ivona; Bansaghi, Zoltan; Spiliopoulos, Stavros; Carchesio, Francesca; Arnold, Dirk; Baierl, Andreas; Zeka, Bleranda; Kaufmann, Nathalie C.; Taieb, Julien; Iezzi, Roberto
- Abstract
CIREL, a prospective, Europe-wide, observational study aimed to assess the real-world feasibility and tolerability of irinotecan-based transarterial chemoembolization (LP-irinotecan TACE) for unresectable colorectal cancer liver metastases with regard to the treatment plan and adverse events (AEs). CIREL enrolled 152 eligible patients (≥18 years) with liver-only or dominant metastases treated with LP-irinotecan TACE following a multidisciplinary tumor board decision. Data were prospectively collected for baseline, the number of planned and performed sessions, and technical information and safety according to CTCAE 4.03/5.0. Results from 351 analyzed treatment sessions showed technical success for 99% of sessions, and 121 patients (79%) completed all planned sessions. Further, 60% of sessions were performed using opioids, 4% intra-arterial anesthetics, and 25% both. Additionally, 60% of patients experienced at least one peri-interventional AE of any grade; 8% of grade 3–4. Occurrence of AEs was related to larger liver-involvement (p < 0.001), bi-lobar disease (p = 0.002), and larger beads (p < 0.001). Using corticosteroids together with antiemetics showed reduced and lower grade vomiting (p = 0.01). LP-irinotecan TACE was tolerated well and had a high proportion of completed treatment plans. This minimally invasive locoregional treatment can be used together with concomitant systemic therapy or ablation.
- Subjects
EUROPE; COLORECTAL liver metastasis; CHEMOEMBOLIZATION; SCIENTIFIC observation; ABLATION techniques; POSTOPERATIVE nausea &; vomiting
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 20, p6178
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11206178