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- Title
Attenuated Neuropathic Pain in CaV3.1 Null Mice.
- Authors
Heung Sik Na; Soonwook Choi; Junesun Kim; Joonoh Park; Hee-Sup Shin
- Abstract
To assess the role of a1G T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (a1G -/-), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The a1G -/- mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of a1G T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of a1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.
- Publication
Molecules & Cells (Springer Nature), 2008, Vol 25, Issue 2, p242
- ISSN
1016-8478
- Publication type
Article
- DOI
10.1016/s1016-8478(23)17576-5