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- Title
Comparative Studies on the GABA-Transaminase Immunoreactivity in Rat and Gerbil Brains.
- Authors
Tae-Cheon Kang; Seung-Kook Park; Jae Hoon Bahn; Joong Sik Chang; Sung-Woo Cho; Soo Young Choi; Moo Ho Won
- Abstract
γ-Aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the central nervous system (CNS). Degradation of GABA in the CNS is catalyzed by the action of GABA transaminase (GABA-T). However, the neuroanatomical characteristics of GABA-T in the gerbil, which is a useful experimental animal in neuroscience, are still unknown. Therefore, we performed a comparative analysis of the distribution of GABA-T in rat and gerbil brains using immunohistochemistry. GABA-T immunoreactive neurons were observed in the regions which contained GABAergic neurons of both animals: corpus striatum; substantia nigra, pars reticulata; septal nucleus: and accumbens nucleus. GABA-T + neurons were restricted to layers III and V in the rat. Unlike the rat GABA-T + neurons were observed in layers II, III, and V of the gerbil cerebral cortex. These results suggest that the expression of GABA-T in the gerbil brain may be similar to that in the rat brain, except in the cerebral cortex.
- Subjects
AMINOBUTYRIC acid; AMINO acids; NEUROTRANSMITTERS; CENTRAL nervous system; GABA
- Publication
Molecules & Cells (Springer Nature), 2001, Vol 11, Issue 3, p321
- ISSN
1016-8478
- Publication type
Article
- DOI
10.1016/s1016-8478(23)17042-7