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- Title
Endometrial Stromal Sarcomas: A Revision of Their Potential as Targets for Immunotherapy.
- Authors
Tuyaerts, Sandra; Amant, Frédéric
- Abstract
Endometrial stromal sarcomas are a subtype of uterine sarcomas that are characterized by recurrent chromosomal translocations, resulting in the expression of tumor-specific fusion proteins that contribute to their tumorigenicity. These characteristics make the translocation breakpoints promising targets for immunotherapeutic approaches. In this review, we first describe the current knowledge about the classification of endometrial stromal sarcomas, and their molecular and genetic characteristics. Next, we summarize the available data on the use of translocation breakpoints as immunotherapeutic targets. Finally, we propose a roadmap to evaluate the feasibility of immunologic targeting of the endometrial stromal sarcoma-specific translocations in patients with recurrent disease.
- Subjects
TREATMENT of endometrial cancer; CANCER treatment; SARCOMA; CHROMOSOMAL translocation; STROMAL cells; CANCER immunotherapy
- Publication
Vaccines, 2018, Vol 6, Issue 3, p56
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines6030056