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- Title
Cellular Factors Targeting APCs to Modulate Adaptive T Cell Immunity.
- Authors
Visperas, Anabelle; Jeongsu Do; Booki Min
- Abstract
The fate of adaptive T cell immunity is determined by multiple cellular and molecular factors, among which the cytokine milieu plays the most important role in this process. Depending on the cytokines present during the initial T cell activation, T cells become effector cells that produce different effector molecules and execute adaptive immune functions. Studies thus far have primarily focused on defining how these factors control T cell differentiation by targeting T cells themselves. However, other non-T cells, particularly APCs, also express receptors for the factors and are capable of responding to them. In this review, we will discuss how APCs, by responding to those cytokines, influence T cell differentiation and adaptive immunity.
- Subjects
ADENOMATOUS polyposis coli genetic testing; CD4 antigen; T cell differentiation; CYTOKINES; NONLYMPHOID leukemia
- Publication
Journal of Immunology Research, 2014, p1
- ISSN
2314-8861
- Publication type
Article
- DOI
10.1155/2014/750374