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- Title
Glioblastoma multiforme and hepatitis B: do the right thing(s).
- Authors
PURCHIARONI, F.; BEGINI, P.; MINNITI, G.; GALLINA, S.; FAVE, G. DELLE; MARIGNANI, M.
- Abstract
OBJECTIVE: Hepatitis B virus (HBV) reactivation is a well-known complication related to immunosuppression. Clinical manifestations of HBV relapse range from self-limiting anicteric hepatitis to acute hepatic failure. Temozolomide (TMZ) is an alkylating agent used for the treatment of glioblastoma multi-forme (GBM), the most common and deadliest of malignant primary brain tumors. CASE REPORT: We report the case of a 52-year old man with a history of serological positivity for hepatitis B surface antigen (HBsAg) who was diagnosed with GBM. Since the tumor was multi-focal and thus inoperable, the patient received radiotherapy with concomitant TMZ and corticosteroids, without a prophylactic therapy for HBV infection. Acute hepatitis developed five months later the beginning of anticancer therapy. We started antiviral entecavir, which led to a decrease of HBV-DNA titer to 20 IU/ml, allowing the prosecution of the TMZ therapy. CONCLUSIONS: Up to now only four other cases of HBV relapse during TMZ therapy have been reported in literature. These cases underline the need of HBV screening and antiviral prophylaxis before starting TMZ administration.
- Subjects
HEPATITIS B virus; GLIOBLASTOMA multiforme; HEPATITIS B; TEMOZOLOMIDE; ANTIGENS
- Publication
European Review for Medical & Pharmacological Sciences, 2014, Vol 18, Issue 23, p3629
- ISSN
1128-3602
- Publication type
Article