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- Title
Role of the NO-cGMP-K<sup>+</sup> channels pathway in the peripheral antinociception induced by α-bisabolol.
- Authors
Ortiz, Mario I.; Cariño-Cortés, Raquel; Muñoz-Pérez, Víctor M.; Salas-Casas, Andrés; Castañeda-Hernández, Gilberto
- Abstract
The aim of this study was to examine if the peripheral antinociception of α-bisabolol involves the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis followed by K+ channel opening in the formalin test. Wistar rats were injected in the dorsal surface of the right hind paw with formalin (1%). Rats received a subcutaneous injection into the dorsal surface of the paw of vehicles or increasing doses of α-bisabolol (100–300 µg/paw). To determine whether the peripheral antinociception induced by α-bisabolol was mediated by either the opioid receptors or the NO-cGMP-K+ channels pathway, the effect of pretreatment (10 min before formalin injection) with the appropriate vehicles, naloxone, naltrexone, NG-nitro-l-arginine methyl ester (L-NAME), 1H-[1,2,4]-oxadiazolo[4,2-a]quinoxalin-1-one (ODQ), glibenclamide, glipizide, apamin, charybdotoxin, tetraethylammonium, or 4-aminopyridine on the antinociceptive effects induced by local peripheral α-bisabolol (300 µg/paw) were assessed. α-Bisabolol produced antinociception during both phases of the formalin test. α-Bisabolol antinociception was blocked by L-NAME, ODQ, and all the K+ channels blockers. The peripheral antinociceptive effect produced by α-bisabolol was not blocked by the opioid receptor inhibitors. α-Bisabolol was able to active the NO-cGMP-K+ channels pathway to produce its antinoceptive effect. The participation of opioid receptors in the peripheral local antinociception induced by α-bisabolol is excluded.
- Subjects
CYCLIC guanylic acid; SUBCUTANEOUS injections; LABORATORY rats; OPIOID receptors; ION channels; METHYL formate; FORMALDEHYDE
- Publication
Canadian Journal of Physiology & Pharmacology, 2021, Vol 99, Issue 10, p1048
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2020-0744