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- Title
[18-C-6H<sub>3</sub>O<sup>+</sup>]: an in-situ generated macrocyclic complex and an efficient, novel catalyst for synthesis of pyrano[2,3-c]pyrazole derivatives.
- Authors
Mishra, Manisha; Jomon, K. J.; Krishnan, V. R. Sriram; Nizam, Aatika
- Abstract
Synthesis of small aromatic heterocycles is of greater importance in the organic chemistry due to their vibrant applications in pharmaceuticals, agrochemicals and veterinary products. Pyranopyrazoles are one such class of heterocycles associated with numerous applications. Hence herein we report a multicomponent crown ether catalyzed, ultrasound irradiated methodology to make different functionalized pyranopyrazoles in a single step. This technique involves the in-situ generation of [18-C-6H3O+][OH−] complex, which in turn activates the aromatic aldehyde and aids in the facile nucleophilic addition.
- Subjects
HETEROCYCLIC compounds; CHEMICAL synthesis; ORGANIC chemistry; CROWN ethers; ORGANIC cyclic compounds
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-70665-z