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- Title
GC-MS, HPLC Profiling, Antioxidant, Antimicrobial and Cytotoxicity Studies of Malcolmia Africana Leaves.
- Authors
Bokhari, Tanveer Hussain; Rasool, Nasir; Riaz, Maryam; Riaz, Muhammad; Hina, Saira; Tareen, Rasool Buksh; Bukhari, Iftikhar Hussain; Zubair, Muhammad; Bukhari, Shazia Anwer; Shahid, Muhammad
- Abstract
Plants are known to be the richest source of natural antioxidant and antimicrobial properties. The use of herbs and medicinal plants as the first medicines is a universal phenomenon. The present study was carried out to examine the antioxidant, antimicrobial and cytotoxicity potential Malcolmia africana leaves extract, fraction, essential oil and fixed oil. The whole plant was extracted with absolute methanol and further fractionated with increasing polarity based absolute solvents. Different fractions were taken by solvent extraction method and their antimicrobial activities were determined. The IC50 and % inhibition by linoleic acid oxidation was evaluated for the antioxidant studies. The cytotoxicity of the plant extract and fractions were assayed against human blood erythrocytes (RBCs). The DPPH scavenging and linoleic acid oxidation assays were carried out. Qualitative and quantitative analysis of secondary metabolites was also carried out. The presence of phenolics was also studied by HPLC. The GC-MS analysis of Malcolmia africana essential oil and fixed oil was also carried out.
- Subjects
ANTIOXIDANTS; ANTINEOPLASTIC antibiotics; PHYTOTHERAPY; THERAPEUTIC use of plant extracts; LINOLEIC acid; APPLICATION of pesticides
- Publication
Journal of the Chemical Society of Pakistan, 2014, Vol 36, Issue 3, p473
- ISSN
0253-5106
- Publication type
Article