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- Title
Alanine aminotransferase elevation varies by ethnicity among Asian and Pacific Islander children with overweight or obesity.
- Authors
Lee, Catherine; Schwimmer, Jeffrey B.; Gunderson, Erica P.; Goyal, Nidhi P.; Darbinian, Jeanne A.; Greenspan, Louise C.; Lo, Joan C.
- Abstract
Summary: Background: Limited research on alanine aminotransferase (ALT) screening for metabolic dysfunction‐associated steatotic liver disease (MASLD) among US Asian/Pacific Islander (PI) children necessitates investigation in this heterogeneous population. Objective: Examine ALT elevation among Asian/PI children with overweight or obesity. Methods: Elevated ALT prevalence (clinical threshold) and association with body mass index ≥85th percentile were compared among 18 402 Asian/PI and 25 376 non‐Hispanic White (NHW) children aged 9–17 years using logistic regression. Results: ALT elevation was more prevalent among Asian/PI (vs. NHW) males with overweight (4.0% vs. 2.7%), moderate (7.8% vs. 5.3%) and severe obesity (16.6% vs. 11.5%), and females with moderate (5.1% vs. 3.0%) and severe obesity (10.2% vs. 5.2%). Adjusted odds of elevated ALT were 1.6‐fold and ~2‐fold higher for Asian/PI (vs. NHW) males and females (with obesity), respectively. Filipino, Chinese and Southeast Asian males had 1.7–2.1‐fold higher odds, but Native Hawaiian/PI (NHPI) and South Asian males did not significantly differ (vs. NHW). Filipina and Chinese females with obesity had >2‐fold higher odds, Southeast and South Asian females did not differ and NHPI findings were mixed (vs. NHW). Conclusion: High elevated ALT prevalence among Asian/PI children with overweight and obesity emphasizes the need for MASLD risk assessment and examination of ethnic subgroups.
- Subjects
CALIFORNIA; METABOLIC disorders; NON-alcoholic fatty liver disease; RISK assessment; STATISTICAL correlation; HAWAIIANS; CROSS-sectional method; ASIAN Americans; RESEARCH funding; BODY mass index; SOUTHEAST Asian Americans; LOGISTIC regression analysis; SEX distribution; DISEASE prevalence; DESCRIPTIVE statistics; CHINESE Americans; SOUTH Asian Americans; WHITE people; SEVERITY of illness index; PACIFIC Islander Americans; RACE; ODDS ratio; ALANINE aminotransferase; RESEARCH; CHILDHOOD obesity; COMPARATIVE studies; BIOMARKERS; FILIPINO Americans; DISEASE risk factors; DISEASE complications; ADOLESCENCE; CHILDREN
- Publication
Pediatric Obesity, 2024, Vol 19, Issue 6, p1
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/ijpo.13110