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- Title
Prospects of the Use of Cell Therapy to Induce Immune Tolerance.
- Authors
Wang, Zhenkun; Liu, Xiaolong; Cao, Fenglin; Bellanti, Joseph A.; Zhou, Jin; Zheng, Song Guo
- Abstract
Conditions in which abnormal or excessive immune responses exist, such as autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being. The traditional immunosuppressive drugs used to treat these conditions can lead to decreased immune function, a higher risk of infection, and increased tumor susceptibility. As an alternative therapeutic approach, cell therapy, in which generally intact and living cells are injected, grafted, or implanted into a patient, has the potential to overcome the limitations of traditional drug treatment and to alleviate the symptoms of many refractory diseases. Cell therapy could be a powerful approach to induce immune tolerance and restore immune homeostasis with a deeper understanding of immune tolerance mechanisms and the development of new techniques. The purpose of this review is to describe the current panoramic scope of cell therapy for immune-mediated disorders, discuss the advantages and disadvantages of different types of cell therapy, and explore novel directions and future prospects for these tolerogenic therapies.
- Subjects
IMMUNOLOGICAL tolerance; CELLULAR therapy; GRAFT versus host disease; GRAFT rejection; AUTOIMMUNE diseases
- Publication
Frontiers in Immunology, 2020, Vol 11, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2020.00792