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- Title
Editorial: Innate Immunity in Aquatic Vertebrates.
- Authors
DeWitte-Orr, Stephanie; Edholm, Eva-Stina; Grayfer, Leon
- Abstract
Aquatic vertebrates reside within pathogen-rich environments, with their skin mucosa representing an important barrier to these pathogens, but also a means of pathogen entry. Teleost fish appear to possess greater numbers of innate-like phagocytic B cells than mammals and thus, understanding the roles of these cells during immune responses and how they are affected by vaccination is key to better fish vaccine development. To this end Wu et al. show that while the Nile tilapia IgM SP lo sp B cells (resembling plasma-like cells) possess decreased phagocytic activity compared to the naïve/mature-like IgM SP hi sp B cells, suggesting that B cell differentiation may cause the decrease in phagocytic capacities of bony fish B cells.
- Subjects
NATURAL immunity; VERTEBRATES; IMMUNITY in fish; B cell differentiation; AQUATIC animals; VETERINARY vaccines; PHAGOCYTOSIS; COLONY-stimulating factors (Physiology)
- Publication
Frontiers in Immunology, 2019, Vol 10, p1
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2019.02959