We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pivotal Role of Mitochondria in Macrophage Response to Bacterial Pathogens.
- Authors
Ramond, Elodie; Jamet, Anne; Coureuil, Mathieu; Charbit, Alain
- Abstract
Mitochondria are essential organelles that act as metabolic hubs and signaling platforms within the cell. Numerous mitochondrial functions, including energy metabolism, lipid synthesis, and autophagy regulation, are intimately linked to mitochondrial dynamics, which is shaped by ongoing fusion and fission events. Recently, several intracellular bacterial pathogens have been shown to modulate mitochondrial functions to maintain their replicative niche. Through selected examples of human bacterial pathogens, we will discuss how infection induces mitochondrial changes in infected macrophages, triggering modifications of the host metabolism that lead to important immunological reprogramming.
- Subjects
MITOCHONDRIA; LIPID synthesis; ENERGY metabolism; INTRACELLULAR pathogens; PATHOGENIC microorganisms
- Publication
Frontiers in Immunology, 2019, Vol 10, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2019.02461