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- Title
A controlled trial of treatment of acquired immunodeficiency in severe measles with thymic humoral factor.
- Authors
Beatty, D. W.; Handzel, Z. T.; Pecht, Marit; Ryder, C. R.; Hughes, Jane; McCabe, Karen; Trainin, N.
- Abstract
A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection, An increased ratio of helper to suppressor T cells (OKT4/OKT8 ratio) and a greater lymphocyte transformation response to phytohaemagglutin was seen in those children receiving THF. We conclude that THF treatment helps to prevent the development of complications particularly secondary viral infections possibly by enhancing cell-mediated immune responses.
- Subjects
CLINICAL trials; IMMUNODEFICIENCY; MEASLES; LYMPHOCYTE transformation; IMMUNE response; VIRUS diseases; THERAPEUTICS
- Publication
Clinical & Experimental Immunology, 1984, Vol 56, Issue 3, p479
- ISSN
0009-9104
- Publication type
Article