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- Title
JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7.
- Authors
Soleimani-Meigooni, David; Schwetye, Katherine; Angeles, Maria; Ryschkewitsch, Caroline; Major, Eugene; Dang, Xin; Koralnik, Igor; Schmidt, Robert; Clifford, David; Kuhlmann, F.; Bucelli, Robert
- Abstract
JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.
- Subjects
JOHN Cunningham virus; GRANULE cells; NEUROPATHY; LYMPHOPENIA; INTERLEUKIN-7; CENTRAL nervous system diseases; THERAPEUTICS
- Publication
Journal of NeuroVirology, 2017, Vol 23, Issue 1, p141
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1007/s13365-016-0465-0