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- Title
Xanthogranulomatous Cholecystitis, Rare Variant of Chronic Cholecystitis - A Histopathological Study from Kashmir, India.
- Authors
Shafi, Afiya; Singh, Jangbhadur; Ashfaq-ul-Hassan; Kour, Haminder
- Abstract
Background Xanthogranulomatous cholecystitis [XGC] is a rare inflammatory disease of gall bladder characterized by focal or diffuse destructive inflammatory process, with varying proportions of fibrous tissue, acute and chronic inflammatory cells and lipid laden foamy macrophages. Material and Methods The present study is 2 year retrospective study done in a medical college hospital. Forty-one (41) patients of XGC were diagnosed and various histomorphological changes were studied. The age, the sex, clinical features and Ultra sound details of patients were also reviewed and analyzed. It is a close differential diagnosis in most of cases of gall bladder carcinoma, and as such needs to be reported with care. Results The incidence of XGC in our study is 2.92 %.Cases included 25 females and 16 males, showing female dominance. Age ranged from 11 to 75 years, with fifth decade as the commonest age group. Most of the patients presented with pain abdomen followed by dyspepsia and vomiting. Three patients were suspected of mass lesion suggesting carcinoma but later proved to be XGC on histopathology. Ultrasonography revealed diffuse and local thickening of gall bladder wall in almost 35 patients with gall stones in 38 patients. Bile duct was free of any stone. Microscopy revealed mucosal ulceration, foamy macrophages, lymphocytes, plasma cells, eosinophils, giant cells - foreign body type and touton type, fibrosis, cholesterol clefts and bile pigment in varying proportions. Conclusions Although radiology is helpful in detecting various disorders of the gall bladder but many a times fails to differentiate between XGC and malignancy. It is very often misdiagnosed on clinical, radiological, pre operative and intra operative findings. Histopathological evaluation of XGC is the gold standard for diagnosing the lesion. Xanthogranulomatous cholecystitis should be reported carefully, as it mimics and is a close differential of carcinoma gall bladder.
- Subjects
JAMMU &; Kashmir (India); CHOLECYSTITIS; FOAM cells; GALLBLADDER; GALLSTONES; HISTOPATHOLOGY; PLASMA cells
- Publication
JK Practitioner, 2022, Vol 27, Issue 4, p37
- ISSN
0971-8834
- Publication type
Article