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- Title
ENVIRONMENTAL RISK FACTORS ASSOCIATED WITH BILIARY ATRESIA IN RIO GRANDE DO SUL, BRAZIL.
- Authors
Longo, Larisse; Tonin Ferrari, Jéssica; Weber Hoss, Giovana Regina; Sinigaglia Fratta, Leila Xavier; Gonçalves Vieira, Sandra Maria; da Silveira, Themis Reverbel; de Abreu e Silva, Fernando Antônio; Vieira Sanseverino, Maria Teresa; dos Santos, Jorge Luiz
- Abstract
Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient's genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.
- Subjects
ENVIRONMENTAL risk assessment; BILIARY atresia; CYSTIC fibrosis
- Publication
Clinical & Biomedical Research, 2017, Vol 37, Issue 2, p87
- ISSN
2357-9730
- Publication type
Article
- DOI
10.4322/2357-9730.71572