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- Title
EVALUATION OF MUTAGENIC EFFECT OF OMEPRAZOLE AND PROTECTIVE EFFECT OF VITAMIN E IN MICE.
- Authors
Mohsin, Mohd.; Jamadar, M. G.; SaiPrasanna, Balram; Abubaker
- Abstract
Omeprazole -- a gastric proton pump inhibitor used in the treatment of peptic ulcer was tested for mutagenicity in germ cells of mice by sperm-head abnormality assay which is one of the simple methods for the detection of mutagenicity caused by various chemicals. Vitamin E (Tocopherol) which curbs generation of peroxidation products was tested for its protective effect against the mutagenicity caused by omeprazole. One group of mice were taken and given omeprazole orally in the doses of 25, 50 and 75 mg/mouse which corresponds to ¼, ½, ¾ LD50 dose value in mice 50 respectively. Second group of mice were given vitamin E in addition to the same doses of omeprazole. First and second groups of mice were given the drug for a period of five days consecutively and for the second group, in addition to the drug, vitamin E was given for thirty five days. The third control group of animals was fed with distilled water. Mice were sacrificed at the thirty fifth day to collect the sperm samples according to method of Bruce et al. in order to see the effect of the drug in the germ cells of mice. The results indicate that the drug is capable of inducing mutations in germ cells of mice and vitamin E has protective role.
- Subjects
VITAMIN E; LABORATORY mice; OMEPRAZOLE; PROTON pump inhibitors; PEPTIC ulcer; GERM cells
- Publication
International Journal of Pharmacology & Biological Sciences, 2011, Vol 5, Issue 3, p55
- ISSN
0973-6808
- Publication type
Article