We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serum S-100B levels in children with Subacute Sclerosing Panencephalitis.
- Authors
Hocanlı, İbrahim; Çalık, Mustafa; Çakmak, Alpay; Çelik, Hakim; Kocyiğit, Abdürrahim; İşcan, Akın
- Abstract
Objectives: S-100B a protein prevalent in the central nervous system is a peripheral biomarker for blood-brain barrier disruption and neuronal damage. The objective of the study was to investigate the S-100B levels in patients with subacute sclerosing panencephalitis. Materials and methods: A group of 40 patients with SSPE and 40 healthy controls were recruited. Serum S-100B protein concentrations were measured using a commercially available electrochemiluminescence immunoassay (ECLIA) kit, as supplied and according to the manufacturer's standards. Results: Median S-100B levels were 0.095 ± 0.017 µg/L in patients with SSPE and 0.097±0.019 µg/L in the control group. This difference was not statistically significant (p>0.05). The patient group was further subdivided into two subgroups according to the presence or absence of brain atrophy. The S-100B levels were 0.096 ± 0.018 µg/L in the subgroup with atrophy and 0.094±0.014 µg/L in the subgroup without atrophy. This difference was also not statistically significant (p>0.05). Conclusions: Our results suggest that serum S-100B is not a reliable marker for neuronal damage in SSPE.
- Subjects
SUBACUTE sclerosing panencephalitis; BLOOD serum analysis; PEDIATRICS; BIOMARKERS; CENTRAL nervous system; BLOOD-brain barrier
- Publication
Journal of Clinical & Experimental Investigations, 2012, Vol 3, Issue 3, p331
- ISSN
1309-8578
- Publication type
Article
- DOI
10.5799/ahinjs.01.2012.03.0173