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- Title
SYNTHESIS, CHARACTERIZATION AND DPPH SCAVENGING ACTIVITY OF SOME BENZIMIDAZOLE DERIVATIVES.
- Authors
Odame, Felix; Krause, Jason; Hosten, Eric C.; Betz, Richard; Lobb, Kevin; Tshentu, Zenixole R.; Frost, Carminita L.
- Abstract
A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with 1H NMR and IR. The crystal structures of two derivatives, 2-(2- chlorophenyl)-1H-benzimidazole and 2-(1H-benzimidazol-2-yl)-4-nitrophenol, are presented. A study of the DPPH scavenging activity of these compounds showed that 2-(1H-benzimidazol-2-yl)phenol (2), 2-p-tolyl-1Hbenzimidazole (3) and 2-(4-methoxyphenyl)-1H-benzimidazole (7) gave IC50 values 1974, 773 and 800 μM.
- Subjects
BENZIMIDAZOLE derivatives; NUCLEAR magnetic resonance; GAS chromatography/Mass spectrometry (GC-MS); CHLOROPHENYLALANINE; CRYSTAL structure
- Publication
Bulletin of the Chemical Society of Ethiopia, 2018, Vol 32, Issue 2, p271
- ISSN
1011-3924
- Publication type
Article
- DOI
10.4314/bcse.v32i2.8