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- Title
Favipiravir Treatment Prolongs Survival in a Lethal BALB/c Mouse Model of Ebinur Lake Virus Infection.
- Authors
Geng, Jingke; Ren, Nanjie; Yang, Cihan; Wang, Fei; Huang, Doudou; Rodriguez, Sergio; Yuan, Zhiming; Xia, Han
- Abstract
Orthobunyavirus is the largest and most diverse genus in the family Peribunyaviridae. Orthobunyaviruses are widely distributed globally and pose threats to human and animal health. Ebinur Lake virus (EBIV) is a newly classified Orthobunyavirus detected in China, Russia, and Kenya. This study explored the antiviral effects of two broad-spectrum antiviral drugs, favipiravir and ribavirin, in a BALB/c mouse model. Favipiravir significantly improved the clinical symptoms of infected mice, reduced viral titer and RNA copies in serum, and extended overall survival. The median survival times of mice in the vehicle- and favipiravir-treated groups were 5 and 7 days, respectively. Favipiravir significantly reduced virus titers 10- to 100-fold in sera at all three time points compared to vehicle-treated mice. And favipiravir treatment effectively reduced the virus copies by approximately 10-fold across the three time points, relative to vehicle-treated mice. The findings expand the antiviral spectrum of favipiravir for orthobunyaviruses in vivo.
- Subjects
KENYA; RUSSIA; LABORATORY mice; MICE; VIRUS diseases; ANIMAL disease models; OVERALL survival; ANTIVIRAL agents; RIBAVIRIN
- Publication
Viruses (1999-4915), 2024, Vol 16, Issue 4, p631
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v16040631