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- Title
Current concepts in the diagnosis and management of antiphospholipid syndrome and ocular manifestations.
- Authors
Uludag, Gunay; Onghanseng, Neil; Tran, Anh N. T.; Hassan, Muhammad; Halim, Muhammad Sohail; Sepah, Yasir J.; Do, Diana V.; Nguyen, Quan Dong
- Abstract
Antiphospholipid syndrome (APS) is an autoimmune disorder associated with obstetrical complications, thrombotic complications involving both arteries and veins, and non-thrombotic manifestations affecting multiple other systems presenting in various clinical forms. Diagnosis requires the presence of antiphospholipid antibodies. The exact pathogenesis of APS is not fully known. However, it has recently been shown that activation of different types of cells by antiphospholipid antibodies plays an important role in thrombosis formation. Ocular involvement is one of the important clinical manifestations of APS and can vary in presentations. Therefore, as an ophthalmologist, it is crucial to be familiar with the ocular findings of APS to prevent further complications that can develop. Furthermore, the ongoing identification of new and specific factors contributing to the pathogenesis of APS may provide new therapeutic options in the management of the disease in the future.
- Subjects
ANTIPHOSPHOLIPID syndrome; OCULAR manifestations of general diseases; DIAGNOSIS; PHOSPHOLIPID antibodies; DISEASE management; CONCEPTS
- Publication
Journal of Ophthalmic Inflammation & Infection, 2021, Vol 11, Issue 1, p1
- ISSN
1869-5760
- Publication type
Article
- DOI
10.1186/s12348-021-00240-8