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- Title
Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes.
- Authors
Davis, Jeffery T.; Gale, Philip A.; Okunola, Oluyomi A.; Prados, Pilar; Iglesias-Sánchez, Jose Carlos; Torroba, Tomás; Quesada, Roberto
- Abstract
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the natural product prodigiosin, a tripyrrolic molecule produced by microorganisms such as Streptomyces and Serratia, facilitates chloride/bicarbonate exchange (antiport) across liposomal membranes. Higher concentrations of simple synthetic molecules based on a 4,6-dihydroxyisophthalamide core are also shown to facilitate this antiport process. Although it is well known that proteins regulate Cl−/HCO3− exchange in cells, these results suggest that small molecules may also be able to regulate the concentration of these anions in biological systems.
- Subjects
MOLECULES; BICARBONATE ions; CHLORIDES; ANIONS; NUCLEAR magnetic resonance spectroscopy; LIPOSOMES; MICROORGANISMS; ION selective electrodes; CHLORIDE-bicarbonate exchange
- Publication
Nature Chemistry, 2009, Vol 1, Issue 2, p138
- ISSN
1755-4330
- Publication type
Article
- DOI
10.1038/nchem.178