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- Title
ASPECTOS MACROSCÓPICOS E HISTOLÓGICOS DA MUCOSA GÁSTRICA DE RATOS WISTAR E SUA UTILIZAÇÃO EM MODELO DE ÚLCERAS GÁSTRICAS.
- Authors
De Carvalho, Camilo Amaro; Fernandes, Kenner Moraes; da Matta, Sérgio Luis Pinto; Fonseca, Claudio César; Pinto, Rogério; De Oliveira, Leandro Licursi
- Abstract
The search of new drugs and the use of animal experimentation had been contributed excessively to the development of the health, of the science and technology, promoting along the years the discovery of prophylactic measured and treatments of illnesses that affect the human beings. Animals of several species have been used from the origins of the civilization for the scientific development, but among all of the experimental models to the which peptic ulcers can be induced, the rats Wistar, doubtless, is the used. The objective of this work was to accomplish an anatomical and histological description. Anatomically, the stomach of the Wistar rat (Rattus norvegicus) is located in the abdominal cavity in the ventral midline in the left portion, caudal to the liver. This body can be divided into two regions glandular and non glandular. These regions are separated by the folded edge that makes the division between the keratinized stratified squamous epithelium that lines the portion of exfoliation and the simple cubic epithelium lining the glandular stomach. The exfoliation portion extending from the esophagus to the bank folded, the glandular region already meets the body and pyloric antrum. The anatomical and histological description, combined with biochemical and physiological, are extremely important in scientific research and the search for new drugs. Thus, this work will contribute to the improvement of studies aimed at the use of rats as an experimental model of gastric ulcers.
- Subjects
VETERINARY pathology; RAT diseases; ETIOLOGY of peptic ulcers; LIVER diseases; DISEASES; RESEARCH
- Publication
Archives of Veterinary Science, 2011, Vol 16, Issue 1, p44
- ISSN
1517-784X
- Publication type
Article
- DOI
10.5380/avs.v16i1.17926