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- Title
The Relationship Between Fibronectine Levels and Oxidation - Glycosylation End Products in Type 1 Diabetic Patients.
- Authors
Basýnoðlu, Filiz; Kural, Alev; Saðlam, Zuhal Aydan; Koldas, Macit; Döventaþ, Yasemin E.; Seval, Hatice; Coskun, Cihan; öztürk, Hümeyra
- Abstract
Purpose: Fibronectin might play an important role in pathogenesis and progression of chronic diabetic complications. The aim of this study is to estimate the plasma concentrations of fibronectin, AGEs (Advanced Glycosylation End Products), AOPPs (Advanced Oxidation Protein Products) T1DM (Type 1 Diabetes Mellitus) patients as well as the relationship between each other and diabetic complications. Material and Methods: Forty T1DM patients attending to the Diabetes and Endocrinology outpatient clinic in Haseki Hospital and 17 healthy volunteers as control group were included in this study. AGEs and AOPPs were measured spectrophotometrically and fibronectin was measured with nephelometric method. Results: Fibronectin levels ofr diabetic patients were significantly higher than control group (p<0.05). There was not any significant difference in fibronectin levels between patients with and without diabetic complications. In addition, no statistically significant difference was observed in AGE and AOPP levels among diabetic patients and control group. No correlation was determined between plasma fibronectin and AGE and AOPP levels (r=0.4) either. Conclusion: No significant correlation was determined between fibronectin levels and AGE and AOPP which play an important role in progression of diabetic complications in T1DM. The lack of significant difference between healthy controls and patients with T1DM suggests that treatment counteracts the increase in free radical production.
- Subjects
FIBRONECTINS; DIABETES complications; GLYCOSYLATION; SPECTROPHOTOMETRY; FREE radical pathophysiology; OXIDATION
- Publication
Erciyes Medical Journal / Erciyes Tip Dergisi, 2010, Vol 32, Issue 2, p81
- ISSN
2149-2247
- Publication type
Article