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- Title
Serum tryptase levels in patients with post-acute COVID-19 syndrome.
- Authors
HADAK, Ana; PREMEC, Durdica; PERKOVIC, Marina; DOLENEC, Vanja; BOZAN, Marina; NEDELJKOVIC, Vanja; KELAVA, Tomislav; MARKOVIC, Ivan
- Abstract
OBJECTIVES: to investigate the difference in serum tryptase levels between post-acute COVID-19 syndrome (PACS) patients and controls. BACKGROUND: PACS has been defined as symptoms that persist for more than 3 months after the onset of COVID-19. The pathogenesis is still unknown, but mast cell activation has been proposed as one of the mechanisms, and increased serum tryptase levels have been demonstrated in PACS patients. METHODS: A total number of 133 patients were included: 50 with PACS, 37 asymptomatic COVID-19 convalescents, and 46 controls with a negative history of COVID-19. Serum tryptase levels were determined in all participants. RESULTS: There was no significant difference in serum levels of tryptase among the groups. CONCLUSION: the role of mast cell activation in PACS remains unclear and further research is needed to fill the gaps in understanding the pathogenesis of this complex and heterogeneous disorder
- Subjects
POST-acute COVID-19 syndrome; COVID-19; TRYPTASE; MAST cells; MAST cell disease
- Publication
Bratislava Medical Journal / Bratislavské Lekárske Listy, 2024, Vol 125, Issue 5, p318
- ISSN
0006-9248
- Publication type
Article
- DOI
10.4149/BLL_2024_47